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Nepafenac is a non-steroidal anti-inflammatory drug (NSAID)
14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
2016 Apr 5
8-fold increase in GPR120 mRNA expression
Wallace JL
PF-5274857 773 Nepafenac is a non-steroidal anti-inflammatoryPF 5274857 is a potent, orally active and selective hedgehog (Hh) signaling pathway inhibitor with an IC50 of 5. 8 nM and a Ki of 4. 6 nM. PF 5274857 was found to effectively penetrate the blood brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF 5274857 was orally available and metabolically stable in vivo. PF 5274857 is a potentially attractive clinical candidate for
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