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Heclin does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys
which is nontoxic to cells per se
Blaquiere N
including all isoforms of PI3K (less than 25% inhibition when tested at 1 μM against Invitrogen kinase panel)
A 419259 also potently induces apoptosis in K-562 cells beginning at 0
APTO-253 eptor Agonist Heclin does not block E2APTO 253 (LOR 253, LT 253) inhibits c Myc expression and selectively induces CDKN1A (p21), promotes G0 G1 cell cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO 253 is also an inducer of KLF4 (Krppel like factor 4). Product information CAS Number: 916151 99 0 Molecular Weight: 367. 38 Formula: C22H14FN5 Chemical Name: 2 (5 fluoro 2 methyl 1H indol 3 yl) 1H imidazo[4,5 f][1,10]phenanthroline Smiles: