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mg/kg once per day to impair tumor growth in an SW480 colon carcinoma xenograft model
Chemical Name: 4-((5-amino-1-(2
third-generation cephalosporin antibiotic with bactericidal activity
15(6):1306-1312
BIIB021 D5 every 24 hoursBIIB021, also known as CNF2024, is an orally active, purine scaffold, small molecule inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90 inhibitor CNF2024 specifically blocks active HSP90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this may result in the inhibition of cellular proliferation in susceptible tumor