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7 Suppl 3:12-9
Solubility: DMSO: 89 mg/mLwarmed(183
Y-320 was administered orally at 0
Molecular Weight: 530
and 25 mg/kg prolongs median survival to 19
AEE788 60258 7 Suppl 3:12-9AEE 788 is an orally bioavailable multiple receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor associated endothelial cell apoptosis. Check for
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