hSMG-1 inhibitor 11e DE-IN-2 for 24 hours) shows substantial

for 24 hours) shows substantial bactericidal activity against S

InChi: InChI=1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12

InChiKey: UIPQURHVPOBFKI-VRNPKMDQSA-N

InChi: InChI=1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12

Chemical Name: (8Z)-8-[(1H-imidazol-4-yl)methylidene]-6H

hSMG-1 inhibitor 11e DE-IN-2 for 24 hours) shows substantialhSMG 1 inhibitor 11e is a potent and selective hSMG 1 kinase inhibitor with an IC50 of <0. 05 nM. hSMG 1 inhibitor 11e shows >900 fold selectivity over mTOR (IC50 of 45 nM), PI3K (IC50s of 61 nM and 92 nM) and CDK1 CDK2 (IC50s of 32 M and 7. 1 M). Product information CAS Number: 1402452 10 1 Molecular Weight: 517. 60 Formula: C26H27N7O3S Chemical Name: 1 {4 [4 (2 {[3 (dimethylsulfamoyl) 4 methylphenyl]amino}pyrimidin 4 yl)pyridin 2 yl]phenyl} 3