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1 ng/mL of VEGF at concentrations of 10 μM and 100 μM
4S)-2-(5-{6-[(2S
InChi: InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28
Formula: C29H37Cl3N6O
CAS Number: 1638211-05-8
ARL 17477 dihydrochloride B2 Ligand 1 ng/mL of VEGF atARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17M for nNOS and endothelial NOS, respectively . Neuronal NOS (nNOS) plays an important role in the development of ischaemic brain necrosis while endothelial NOS (eNOS) protects brain tissue through increasing ischaemic regional cerebral blood flow . In rats after transient MCA occlusion, ARL 17477 (1mg kg, 3mg kg and 10mg
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