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Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys
56(19):7498-500
and represses tumor growth
Molecular Weight: 353
P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid Resistance analysis of the hepatitisP5091 (P005091), CAS No. 882257 11 6, is a novel potent and selective inhibitor of ubiquitin specific protease 7 (USP7) with an IC50 ~4. 2 M. It does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). It induces apoptosis in MM cells resistant to conventional and bortezomib therapies. Biochemical and genetic studies showed that blockade of HDM2 and p21 abrogated P5091 induced cytotoxicity. In animal tumor model
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