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reduces joint damage in two murine models of osteoarthritis
PF-4136309 is potent in inhibiting CCR2 mediated signaling events such as intracellular calcium mobilization and ERK (extracellular signal-regulated kinase) phosphorylation with IC50 values of 3
InChiKey: ZRDMJAGESDWCMV-RGGAHWMASA-K
InChi: InChI=1S/C34H38N4O6
6 μM in DPPH and cytochrome-c reduction assays
BRL-50481 Catalog No.:M18258-C reduces joint damage in twoBRL 50481 is a novel and selective inhibitor of PDE7 with IC50s of 0. 15, 12. 1, 62 and 490 M for PDE7A, PDE7B, PDE4 and PDE3, respectively. Product information CAS Number: 433695 36 4 Molecular Weight: 244. 27 Formula: C9H12N2O4S Chemical Name: N,N,2 trimethyl 5 nitrobenzene 1 sulfonamide Smiles: CN(C)S(=O)(=O)C1C=C(C=CC=1C)N(=O)=O InChiKey: IFIUFCJFLGCQPH UHFFFAOYSA N InChi: InChI=1S C9H12N2O4S c1 7 4 5 8(11(12)13)6 9(7)16(14,15)10(2)3 h4 6H,1 3H3
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