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metabolic stability
Solubility: (25°C) DMSO: 11 mg/mL(21
T cell gelatinases mediate basement membrane transmigration in vitro
Molecular Weight: 580
It inhibits HDAC3 with IC50 of 289 nM
IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60319 metabolic stabilityIRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to