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77(1):58-69
PubMed Central PMCID: PMC3155288
It can also reduce the self-renewal and proliferation of GBM-derived cancer stem–like cells
InChiKey: PJFZOGMSPBHPNS-WICJZZOFSA-N
Heclin was used at 10-30 µM final concentration in various in vitro assays
G-749 - CAS# 1457983-28-6 Catalog No.:M6514-10 77(1):58-69G 749, CAS No. 1457983 28 6, is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3 ITD, FLT3 D835Y, FLT3 ITD N676D, and FLT3 ITD F691L in cellular assays. G 749 retained its inhibitory potency in various drug resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients