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falciparum NSG (NOD-scid IL-2Rγnull) mouse models (0
ClH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19
InChi: InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H
InChiKey: KWGUETFSHQZXMA-UHFFFAOYSA-N
RU-SKI 43 behaved as an uncompetitive inhibitor (Ki = 7
YM-53601 ra B inhibitor 1 falciparum NSG (NOD-scid IL-2Rγnull) mouseYM 53601 is an inhibitor of squalene synthase activity that acts by lowering cholesterol as well as triglycerides. YM 53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM 53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid lowering agent. YM 53601 is also an inhibitor of farnesyl diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV
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