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Stereoselective synthesis of β-naltrexol
Solubility: DMSO: 58 mg/mL(199
TIC-10 isomer was found to be inactive
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)C3C=CC=CC=3)C(=O)N2[C@H]1C(O)=O |^1:0|
InChi: InChI=1S/C10H16N2O5S/c13-8(14)4-2-1-3-7-9-6(5-18(7
5, 15-DPP Size:Contact [email protected] for quotation Stereoselective synthesis of β-naltrexol5,15 diphenylporphyrin (5,15 DPP) is a selective STAT3 SH2 antagonist . Stat3 is constitutively activated in many human cancers. Stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell cycle regulators and inducers of angiogenesis . Aberrant STAT3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases . In vitro: 5,15 DPP