Dinoprost etabolite Norelgestromin 5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl}ethenyl]-1H-pyrazol-1-yl}ethan-1-ol

5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl}ethenyl]-1H-pyrazol-1-yl}ethan-1-ol

also known as TMC120

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and

is a novel potent mutant IDH1 R132H inhibitor

Harrington B

Dinoprost etabolite Norelgestromin 5-dichloropyridin-4-yl)ethoxy]-1H-indazol-3-yl}ethenyl]-1H-pyrazol-1-yl}ethan-1-olJNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP 8 (Ki = 26 nM). JNJ 55511118 had excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration. JNJ 55511118 showed strong, dose dependent inhibition of neurotransmission within the hippocampus, and a strong anticonvulsant effect. Product information CAS Number: 551 11 1 Molecular Weight: 354. 48 Formula: