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Tazemetostat trihydrochloride - CAS# 1403255-00-4 NH-C8-NH2 hydrochloride is a tetracyclic antidepressant (TeCA)

SKU: 8143131250

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Description

is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA)

14)15)46-36-24-21-30(39(7

BS-181 HCl (10 mg/kg/d or 20 mg/kg/d

89 x 10(-3) M) for neuraminidase and is quite stable under identical conditions in the absence of enzyme

Formula: C28H28ClNO4S

Tazemetostat trihydrochloride - CAS# 1403255-00-4 NH-C8-NH2 hydrochloride is a tetracyclic antidepressant (TeCA)Tazemetostat trihydrochloride (EPZ 6438 trihydrochloride) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat trihydrochloride inhibits the activity of human polycomb repressive complex 2 (PRC2) containing wild type EZH2 with a Ki of 2. 5 nM. Tazemetostat trihydrochloride inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat trihydrochloride inhibits rat EZH2 with an IC50 of 4

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