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whereas normal cells remain unaffected
3-dimethyl-2-oxo-2
Smiles: CN(C)C1C=CC(=CC=1)C1NC2=CC=C(C=C2N=1)C1NC2=CC=C(C=C2N=1)N1CCN(C)CC1
Smiles: CN1CCN(CC2C=CC(=CC=2)C2=CN([C@@H]3CC[C@@H](O)CC3)C3=NC(NCCC4CC4)=NC=C23)CC1
Villaseñor AG
LC-2, PROTACs for KRAS orvastatin (hemicalcium salt) whereas normal cells remain unaffectedLC 2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines. Product information CAS Number: 2502156 03 6 Molecular Weight: 1132. 78 Formula: C59H71ClFN11O7S Chemical Name: (2S,4R) 1 [(2S) 2 (3 {3 [(2S) 2 ({[7 (8
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