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Telatinib (BAY 57-9352) c acid Neurotoxicology

SKU: 81609674603

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Description

Neurotoxicology

PubMed Central PMCID: PMC5352210

PubMed PMID: 25712356

41(58)37(55)34(25)47(50

InChi: InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H

Telatinib (BAY 57-9352) c acid NeurotoxicologyTelatinib, aslo known as BAY 57 9352, is a potent and orally active VEGFR 2 and VEGFR 3 tyrosine kinase inhibitor. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Telatinib treatment was well tolerated. The observed single agent antitumor activity in heavily pretreated CRC patients was limited. Pharmacodynamic results are suggestive for the biological activity of telatinib justifying

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