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PubMed Central PMCID: PMC4201083
PubMed PMID: 21933026
CAS Number: 1204144-28-4
InChi: InChI=1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10
9bS)-9-hydroxy-6
SB-705498 - CAS# 501951-42-4 ine (hydrochloride monohydrate) PubMed Central PMCID: PMC4201083SB 705498 is an orally bioavailable, competitive antagonist of the capsaicin mediated activation of TRPV1 receptors (pKis = 7. 6, 7. 5, and 7. 3 for human, rat, and guinea pig, respectively). SB 705498 inhibits the capsaicin , acid , and heat mediated activation of the receptor. SB 705498 was shown to be a potent competitive antagonist of the capsaicin mediated activation of the human TRPV1 receptor (pK(i) = 7. 6) with activity at rat (pK(i) = 7. 5)
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