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InChi: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H
PubMed PMID: 23820456
Smiles: C[C@@H]1CC2=C(NC3=CC=CC=C32)[C@@H](C2C(F)=CC(=CC=2F)/C=C/C(O)=O)N1CC(C)(C)F
is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity
Degenhardt Y
CCG-1423 Catalog No.:M9362-10 InChi: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11HCCG 1423 is a small molecule inhibitor of RhoA transcriptional signaling. CCG 1423 displays activity in several in vitro cancer cell functional assays. CCG 1423 potently (<1 mumol L) inhibits lysophosphatidic acid induced DNA synthesis in PC 3 prostate cancer cells, and whereas it inhibits the growth of RhoC overexpressing melanoma lines (A375M2 and SK Mel 147) at nanomolar concentrations, it is less active on related lines (A375 and SK Mel 28) that
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