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including AKT
CAS Number: 139298-40-1
ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation
InChiKey: DQIJBACZLYDYMW-SRQPLJGDSA-N
Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry in these tumor cells
OSU-T315 - CAS# 2070015-22-2 Size:10mg solid including AKTOSU T315 (ILK IN 1) is a small Integrin linked kinase (ILK) inhibitor with an IC50 of 0. 6 M, inhibiting PI3K AKT signaling by dephosphorylation of AKT Ser473 and other ILK targets (GSK 3 and myosin light chain). OSU T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase dependent apoptosis in an ILK independent manner[2]. OSU T315 causes cell death through apoptosis and autophagy. Product information CAS
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