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6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-Ylpyrazol-4-Yl)pyridin-2-Amine
[Epub ahead of print] PubMed PMID: 26791484
Meeting: 2011 ASCO Annual Meeting
Bromosporine (18 μM) has moderate cytotoxicity in HeLa cells
It improves muscle mitochondrial function too
WS3 - β Cell Proliferation Inducer. CAS# 1421227-52-2 60302 6-Dichloro-3-Fluorophenyl)ethoxy]-5-(1-Piperidin-4-Ylpyrazol-4-Yl)pyridin-2-AmineWS3, CAS No. 1421227 52 2, is a highly potent and selective small molecule that promotes pancreatic cell and RPE cells expansion, identified by a high throughput, cell based screening. It can induce proliferation of mouse R7T1 cells with an EC50 ~0. 074 M, and expansion of primary rat and human cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and adult human
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