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Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5
IWR-1 provides EMT reversal effects by directly suppressing survivin expression
critical dNTP depletion
InChiKey: RFAZNTABYJYOAR-UHFFFAOYSA-N
It inhibits KDM2A at IC50 ~1
SKP2-C25 - Skp2 Inhibitor. CAS# 222716-34-9 60149 Development and biological evaluation ofSKP2 C25, CAS No. 222716 34 9, is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt mediated glycolysis and triggering p53 independent cellular senescence. SKP2 C25 exhibits potent antitumor activities in multiple animal models and cooperates with
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