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RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM
increasing doses) transiently (10-15 min) and dose-dependently increases MAP by up to 15%
Smiles: CC1OC2=C(O)C(=CC=C2C=1C(=O)C1=CC(OC)=C(OC)C(=C1)OC)OC
A total of 102 (84%) of the 122 isolates are negative for indole production
InChiKey: MIKUYHXYGGJMLM-UUOKFMHZSA-N
JAK1-IN-7 18136 RO-5963 is a dual p53-MDM2JAK1 IN 7 is a Janus associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti inflammatory effect. Product information CAS Number: 2241039 81 4 Molecular Weight: 599. 65 Formula: C28H31F2N7O4S Chemical Name: (2R) N (3 {5 fluoro 2 [(2 fluoro 3 methanesulfonylphenyl)amino]pyrimidin 4 yl} 1H indol 7 yl) 3 methoxy 2 (4 methylpiperazin 1 yl)propanamide Smiles:
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