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AES-350 - CAS# 847249-57-4 12841 (S)-CVN424 is a potent G-Protein-Coupled

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Description

(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator

PLX647 dihydrochloride (30 mg/kg BID) is able to prevent bone damage by the tumor cells

Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes

4(5):441-445

This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines

AES-350 - CAS# 847249-57-4 12841 (S)-CVN424 is a potent G-Protein-CoupledAES 350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0. 0244 M and 0. 035 M, respectively. AES 350 is also against HDAC 3, 8, and 11 in an enzymatic activity assay with IC50 values of 0. 187 M, 0. 245 M, and >1M, respectively. AES 350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. Product information CAS Number: 847249 57 4 Molecular Weight: 312. 36 Formula:

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