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is a novel glycine antagonist of NMDA receptor activation
3 μM in cells
Molecular Weight: 482
3 (12): 1091–1096
which continued to grow
GDC-0449 (Vismodegib) - Hedgehog Antagonist. CAS# 879085-55-9 094 is a novel glycine antagonistVismodegib (GDC 0449), CAS No. 879085 55 9, is a potent and specific hedgehog pathway inhibitor with an IC50 of 3 nM. It has been approved by FDA to treat BCC, and also in multiple clinical trials to treat advanced solid tumors. It blocks the activities of the Hedgehog ligand cell surface receptors PTCH and or SMO and suppressing Hedgehog signaling. It prevents multiple ATP binding cassette (ABC) transporters. GDC 0449 also exhibited efficacy in
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