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In animals with severed spinal cords
which may contribute to the formation and malignant progression of gliomas as well as other forms of cancer
It inhibited mTOR
identified by a high-throughput screening
5-a]pyrimidine-3-carbonitrile
PX-478 - Hypoxia-inducible Factor-1α (HIF-1α) Inhibitor. CAS# 685898-44-6 0418 In animals with severed spinalPX 478, CAS No. 685898 44 6, is HIF 1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1 alpha inhibitor PX 478 appears to inhibit hypoxia inducible factor 1 alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation,