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3 L/kg/h in dogs
Netarsudil/latanoprost fixed-dose combination for the treatment of open-angle glaucoma or ocular hypertension
a p38 mitogen-activated protein-kinase inhibitor
PubMed PMID: 22573732
105628-07-7 (HCl)
G007-LK B-PS 3 L/kg/h in dogsG007 LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1 2 inhibitor. G007 LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007 LK was first discovered by Dr. Stefan Krauss's team. Product information CAS Number: 1380672 07 0 Molecular Weight: 529. 96 Formula:
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