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Chemical Name: methyl (15S
Neuroreport
InChi: InChI=1S/C22H31NO3
InChiKey: IGUBBWJDMLCRIK-UHFFFAOYSA-N
Chromosomal translocations of p300 or CBP with MOZ
EN4 MYC inhibitor - CAS# 1197824-15-9 degrader-1 Chemical Name: methyl (15SEN4 is a functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. EN4 functionally and covalently targets an intrinsically disordered region in MYC. EN4 directly targets MYC in cells and reduces MYC and MAX thermal stability. EN4 inhibits MYC activity, downregulates MYC targets, and impairs tumorigenesis. MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting