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PubMed PMID: 17562705
resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis
CAS Number: 872511-34-7
and may inspire novel drug discovery efforts aimed at the development of drugs targeting oncogenic RAS
InChi: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H
WS6 - β Cell Proliferation Inducer. CAS# 1421227-53-3 Catalog No.:M60097-2S PubMed PMID: 17562705WS6, CAS No. 1421227 53 3, is a highly potent and selective small molecule that promotes pancreatic cell proliferation in rodent and human primary islets, identified by a high throughput, cell based screening using rodent pancreatic cells. It can induce proliferation of mouse R7T1 cells with an EC50 ~0. 28 M, and induce up to 4% of rat cells and 3% of human cells to proliferate, with a similar EC50 of 0. 4 M. WS6 induces proliferation of primary rat
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