MS023 - PRMT Inhibitor. CAS# 1831110-54-3 0331 BI-7273 may be useful in

BI-7273 may be useful in further exploring BRD9 bromodomain biology in both in vitro and in vivo settings

Molecular Weight: 503

Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains

DMF (25mg/mL)

even at high MOI

MS023 - PRMT Inhibitor. CAS# 1831110-54-3 0331 BI-7273 may be useful inMS023, CAS No. 1831110 54 3, is a potent, selective and cell permeable type I PRMT inhibitor (catalyzes mono and asymmetric dimethylation of arginine residues) with IC50 of 30 nM, 119 nM, 83 nM, 4 nM and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. It is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. A crystal structure of PRMT6 in complex with MS023 revealed that