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CID 53347902
Epub 2015 Mar 17
Schäfer L
InChi: InChI=1S/C19H22O4/c1-12(2)9-10-22-15-7-5-14(6-8-15)17-16(11-13(3)4)18(20)23-19(17)21/h5-9
and exhibit significant efficacy in PTEN- and PI3K mutant xenograft models
SR-717 lithium - CAS# 2375421-09-1 60295 CID 53347902SR 717 lithium, CAS No. 2375421 09 1, is an agonist of stimulator of interferon genes STING for treating cancer. SR 717 demonstrates broad interspecies and interallelic specificity. SR 717 functions as a direct cyclic guanosine monophosphate adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR 717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant
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