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2013 Nov 21
2018 Jan 11
It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases
WO2015092740A1
Vaswani RG
PQR-309 - CAS# 1225037-39-7 0216 2013 Nov 21PQR 309, CAS No. 1225037 39 7, is an orally bioavailable pan inhibitor of phosphoinositide 3 kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K mTOR kinase inhibitor PQR 309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K mTOR. Activation of
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