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SB-334867 was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX1
2-PMPA at 250 mg/kg
408 and 648 nM for β3
[Epub ahead of print] PubMed PMID: 26678038
Brainard DM
FzM1.8 - CAS# 2204290-85-5 LSB SB-334867 was the first non-peptideFzM1. 8, CAS No. 2204290 85 5, is an allosteric agonist of the Frizzled receptor FZD4. Product information CAS Number: 2204290 85 5 Molecular Weight: 322. 31 Formula: C18H14N2O4 Chemical Name: 3 Hydroxy 5 (3 (naphthalen 2 yl)ureido)benzoic acid Smiles: OC(=O)C1C=C(O)C=C(C=1)NC(=O)NC1=CC2=CC=CC=C2C=C1 InChiKey: XGNNCRZDDAJBFU UHFFFAOYSA N InChi: InChI=1S C18H14N2O4 c21 16 9 13(17(22)23)8 15(10 16)20 18(24)19 14 6 5 11 3 1 2 4 12(11)7 14 h1
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