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Development of the drug was abandoned in January 2011
NCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
Formula: C27H44O4
PD-166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase
Chemical Name: sodium hydrate hydrogen {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonate
AMG 487 - CAS# 473719-41-4 Catalog No.:M10194-2 Development of the drug wasAMG 487 is a potent and selective antagonist of chemokine (C X C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8. 2nM for I IP 10 and I ITAC, respectively. AMG 487 prevents the chemokines I IP 10 and I ITAC from binding to CXCR3. In the cellular assays, AMG 487 inhibits CXCR3 mediated cell migration with IC50 values of 8nM, 15nM and 36nM for I IP 10, I ITAC and MIG, respectively. Product information CAS Number: 473719 41 4 Molecular Weight:
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