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6-3)4(7)8/h6H
GDC-0834 is an anti-arthritis agent that inhibits Bruton's tyrosine kinase
with treatment resulting in marked increases in periosteal bone formation and cortical thickness in ovariectomized monkeys whereas trabecular bone formation is reduced
InChi: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9
(2011) Cell 147(1)
BACE-1 inhibitor 2 6780 6-3)4(7)8/h6HBACE 1 inhibitor 2 is a potent and CNS permeable BACE 1 inhibitor with an IC50 of 1. 5 nM in BACE 1 enzymatic assay. Product information Molecular Weight: 467. 42 Formula: C21H21F4N5O3 Chemical Name: N [3 [(4aS, 6S, 8aS) 2 amino 3, 3 difluoro 6 methyl 4a, 5, 6, 8 tetrahydro 4H pyrano[3, 4 b]pyridin 8a yl] 4 fluorophenyl] 5 (fluoromethoxy)pyrazine 2 carboxamide Smiles: C[C@H]1C[C@H]2CC(F)(F)C(N)=N[C@]2(CO1)C1=CC(=CC=C1F)NC(=O)C1=CN=C(C=N1)OCF InChiKey:
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