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Anti-tumor efficacy of CPI-444±anti-PD-L1 is associated with increased CD8+ cell infiltration and activation in MC38 tumor tissues
Burslem et al (2018) The advantages of targeted protein degradation over inhibition: An RTK case study
Urolithin A exerts a dose- and time-dependent significant arrest at G2/M and S phases after treatments with 50 and 100 μM at 24 and 48 h compared to control cells
Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-β signalling in 7
Warheit DB
NRX-252114 ncristine Anti-tumor efficacy of CPI-444±anti-PD-L1 isNRX 252114 is a potent enhancer of the interaction between catenin, and its cognate E3 ligase, SCF TrCP. NRX 252114 enhances the binding of pSer33 S37A catenin peptide for TrCP with an EC50 of 6. 5 nM and a Kd of 0. 4 nM. NRX 252114 induces mutant catenin degradation. Product information Molecular Weight: 510. 32 Formula: C22H12Cl2F3N3O2S Chemical Name: 2 {4 [(2,6 dichlorophenyl)sulfanyl] 2 oxo 6 (trifluoromethyl) 1,2 dihydropyridine 3 carbonyl} 2,3
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