CNX-1351 - CAS# 1276105-89-5 Catalog No.:M9803-10 3-d]pyrimidin-7-yl]cyclohexan-1-ol

3-d]pyrimidin-7-yl]cyclohexan-1-ol

with antiallergic effects related to histamine antagonism

25(11):1349-52

NCC(O)C1=CC=C(O)C=C1

5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-7

CNX-1351 - CAS# 1276105-89-5 Catalog No.:M9803-10 3-d]pyrimidin-7-yl]cyclohexan-1-olCNX 1351 is a selective covalent Inhibitor of PI3K. In an end point assay, CNX 1351 potently inhibited PI3K and was 20400 times less potent against , , and . CNX 1351 inhibit PI3K signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX 1351 inhibits growth of cells dependent on PI3K. CNX 1351 also inhibits PI3K signaling in vivo and bonds to p110. Product information CAS Number: 1276105 89 5 Molecular