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26)16(23)10(2)19(12
L-Moses binds in the acetylated lysines (KAc) -binding pocket of PfGCN (blue ribbon and sticks) and makes H-bonds (dotted lines) through the triazole to N1436 and the first of a network of four water molecules (red spheres)
Treponemycin
Antosiak A
Smiles: CC(C)CC(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(C)NC(=O)CN)C(C)CC)C(C)CC)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(O)=O
Syk-IN-3 Catalog No.:M15130-2 26)16(23)10(2)19(12Syk IN 3, a potent spleen tyrosine kinase (Syk) inhibitor, extracted from patent WO2011075515A1, compound example 152, has an IC50 of 1 nM. Product information CAS Number: 1312534 69 2 Molecular Weight: 452. 57 Formula: C24H28N4O3S Chemical Name: (1S,4R) 4 hydroxy 2,2 dimethyl 4 (5 {3 methyl 5 [(4 methylpyrimidin 2 yl)amino]phenyl} 1,3 thiazol 2 yl)cyclohexane 1 carboxylic acid Smiles:
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