In fact, many of the best stuff running around is oriented toward the big side (Stoneforge Mystic, Restoration Angel, Teferi, Mage of Zhalfir, Consecrated Sphinx, Vampire Nighthawk, Gray Merchant of Asphodel, Feldon of the Third Path, Azusa, Lost of Seeking, Silklash Spider, Courser of Kruphix, Prophet of Kruphix, Brago, King Eternal, Kuldotha Forgemaster), and thats in addition to creatures specifically designed and included for defense like Walls and other cards with defender
And hey
products like the Shaddoll structure deck, Duel Overload and many different real life packs
Most of the other cards have their place as worthwhile cards in Commander, but Restoration Angel should be feared because its arrival usually heralds the end of someone
Daxos's Torment Speaking of enchantment synergies we have this somewhat demon card