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It shows modest general cytotoxicity
HLCL-61 was used at 25-50 µM final concentration in various in vitro assays
0 µM final concentration in vitro and in cellular assays
with TGI of 88% and 97%
Molecular Weight: 307
AZD2014 - mTOR Inhibitor. CAS# 1009298-59-2 size:2 mg solid It shows modest general cytotoxicityAZD2014, CAS No. 1009298 59 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 2. 8 nM). It displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms , , , = 3. 8 M, >30 M, >30 M and >29 M, respectively) and is inactive against a general panel of over 200 kinases when tested at 10 M. AZD2014 inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235 236 ) IC50 = 0. 2 M, pAKT (S473) IC50
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