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Smiles: CC1=C(CC(=O)N2CCOCC2)C2=CC(=CC=C2N1C(=O)C1C=CC(Cl)=CC=1)OC
InChi: InChI=1S/C19H19N5/c1-19(2
Horm Res Paediatr
Formula: C28H27N5O2S
6-naphthyridine-6-carbonyl]cyclopentyl]oxan-4-amine
SCH900776 lrestatin Smiles: CC1=C(CC(=O)N2CCOCC2)C2=CC(=CC=C2N1C(=O)C1C=CC(Cl)=CC=1)OCSCH900776, also known as MK 8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1 dependent cell cycle arrest in the S and G2 M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA damaging effects of ionizing
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