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Tipifarnib (Zarnestra) Size:10mg solid 14(13):1923-1934

SKU: 36719151172

4.5
USD105.00 USD155.00

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Description

14(13):1923-1934

Molecular Weight: 1115

3390/pathogens4030620

Meractinomycin

including BCWM

Tipifarnib (Zarnestra) Size:10mg solid 14(13):1923-1934Tipifarnib, also known as R115777, is a farnesyltransferase inhibitor that is being investigated in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). It inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive. It inhibits prenylation of the CxxX tail motif, which allows Ras to bind to the membrane where it is active. Without this step the protein cannot

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