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Storage Condition: Powder: 4oC 1 year
which is a concentration that has little or no adverse effect on the host cell (cell viability >80%)
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
PubMed PMID: 25374341
InChi: InChI=1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3
GV-58 60427 Storage Condition: Powder: 4oC 1GV 58 is a potent, selective N and P Q type Ca2+ channels agonist with EC50 of 7. 21 8. 81 uM for N type P Q type Ca2+ channel; 20 fold less potent CDK inhibitor activity. IC50 value: 7. 21 8. 81 uM (N type P Q type Ca2+ channel) Target: Ca2+ channel agonistIn comparison with the parent molecule, (R) roscovitine, GV 58 has a 20 fold less potent cyclin dependent kinase antagonist effect, a 3 to 4 fold more potent Ca2+ channel agonist effect, and 4 fold