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with LC50 values of 41 μM in M1 cells (68 times its activity IC50) and a LC50 greater than 100 μM in HeLa cells
7 and 110 fold selectivity compared to wt-RET and KDR
2013 Nov 28
selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM
Immunoprecipitation experiments revealed that Atglistatin does not interfere with the interaction of ATGL and CGI-58
APX-115 free base - CAS# 1270084-92-8 size:10mg solid with LC50 values of 41APX 115 free base, CAS No. 1270084 92 8, also known as EWHA 18278, is a potent, orally active pan NADPH oxidase (Nox) inhibitor. APX 115 protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice. APX 115 might be a promising therapeutic agent for the treatment of DN because of its pan NOX inhibitory activity, including its NOX5 inhibitory activity, and also owing to its anti inflammatory effect. Product information CAS
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