I cant imagine well see many villains don the Spider-Suit just yet
We have a variety of ways to keep triggering Kardur: the most common is by making token copies of Kardur with cards like Jaxis, the Troublemaker and Orthion, Hero of Lavabrink which trigger his mega goad before dying, but we also have bounce with Skull Collector and reanimate/blink with Rescue from the Underworld
You also want more than a few 1- and 2-drops to make sure you can get your chain going
What we do have is a very good delivery moogle, Final Fantasy 6's Kefka, Tidus and Yuna sharing a very tender kiss (congrats, Tidus x Yuna shippers), Final Fantasy 13's Lightning, and Final Fantasy 14's Emet Selch
The Red creature land has found homes within multiple Magic formats, from Historic and Standard to Pioneer and Commander