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Its drawback may look like its very punishing and can allow the opponent to surprise you via a mid-combat spell, but I never really saw that scenario play out since its damage prevention ability is a a conditional static ability so as long as its on when damage is dealt, it wont be prevented. (Thank you, @fenaris!) It usually plays out somewhat like a colorless Ashenmoor Gouger / Chimeric Idol where you typically dont bother trying to block with it (why am I blocking with my aggro guys anyway?) and, if need be, you cast a spell pre-combat to activate it (typically I used a large coin, like a quarter, to denote whether it was on or off)

SR Super Rare Ultimate Slayer X SPELL Your opponent cannot activate monster effects in response to this card's activation

Yes, toxic does stack

Not that many

Im really curious about that red dino evo chain