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Outside of removal, there's other powerful spells like the game-ender Exsanguinate, and the value engine Lingering Souls, both of which work well with Y'shtola's abilities due to being greater than mana value 3 when cast

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You can throw Blood, Treasures, Equipment, or even artifact creatures

Your opponent then takes 300 damage for every card they lost which can be more than enough damage to finish the game

If this card would be destroyed (by battle or by a card effect): You can remove 2 Halloween Counters from your side of the field instead