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As we're in the middle of spoiler season, some of these cards may eventually be eclipsed by others - though we're confident each of these has the potential to be impactful in Standard (and some of them beyond!) 10 Nowhere to Run Removal That Sticks Around To Annoy Nowhere to Run has a few things going for it

Making each opponent discard a card and drawing an equal number swings the card advantage race in your favor, especially if you have the mana to back up that card draw

This involves missions for unlocking every character and fulfilling specific requirements while playing as some characters

Honorable Mention #2 (#13 Overall) - Response // Resurgence I run this in many of my Commander decks, more so than the next few

It's basically cheating (or, more precisely: a color pie break) that lets red decks get rid of problematic cards like enchantments and guarantees that its target gets out of sight and out of mind, but runs the risk of replacing it with something even worse