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You will have a smattering of disruption from removal to countermagic to targetted discard

Extort is interesting in EDH since each extort trigger will gain you 3 life, and that can be redirected further with cards like Sanguine Bond

The truly impressive part of this card comes when she is first played, as playing her will make all characters attack for three less until the next time this player has a turn

If a creature with toxic deals combat damage to a creature or planeswalker, or if it deals noncombat damage, toxic has no effect and no player gets poison counters

We just saw Soulstone Sanctuary in Foundations, to give a recent example