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You cannot put the counter on it in response

In a four-person game, in order to go off and blow up the world, it has to be three against one

If you draw this card in the mid- to late-game, it has cycling to give you a draw for a better card

There's a billion variations of this combo, but all of them involve a creature that produces at least one additional creature like Hunted Witness or Sengir Autocrat, sacrificing the creature to a repeatable (usually free) sacrifice outlet like Ashnod's Altar, getting the creature back into play with stuff like Nim Deathmantle or Decaying Soil, and finally a card that turns these infinite death triggers into a win like Blood Artist

In particular, Innistrad introduced double-faced transforming cards to reflect its horror inspiration