fragmented card binding of isaac I had trinket + Voodoo Head item. I got only an extra secret room but no extra curse room (it also happened for the subsequent floors) : r/bindingofisaac Luna + Fragmented Card Actually

Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard

While this doesn't seem to be the case, as lead designer Mark Rosewater has already said he's experimented with getting rid of the Reserved List in the past, people see the Reserved List as an unnecessary restriction that only helps the already profiting players

It may seem unfair, but its perfectly legal

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Lets take a closer look at these realms: Istfell is the blue/white world inhabited by Spirits that didnt fall in battle Karfell is the blue/black world plagued by Viking Zombies and one last feral tribe of primal Humans Immersturm is the blue/red world inhabited by warmongering Demons Gnottvold is the red/green world lush with Trolls Bretagard is the green/white world in which Humans thrive Starnheim is the white/black world that is graced by Angels (Valkyrie) and fallen heroes of the battle Surtland is the red/blue world suffering from internal conflict between the frost and fire Giants Skemfar is the black/green world where wood and dark elves lurk